Endocrine Abstracts

Transsphenoidal surgery is the treatment of choice for acromegaly. Cure is defined by normalization of age-related IGF1 and sufficient suppression of GH in the oral glucose tolerance test (OGTT). We investigated, if early postoperative hormone testing gives reliable information whether complete resection of a tumor was achieved and compared these findings with further follow-up data.So far, 22 patients underwent OGTT within a week after surgery, starting...

Leptin acts not only as an anorexigenic hormone but is also involved in the regulation of cell-mediated immunity. However, since the impact of leptin on NK cells is currently elusive, we investigated the body weight-dependent leptin effects on NK cells numbers and function.In a first set of experiments leptin and MADB106 tumor cells were injected intravenously in male lean and diet-induced obese Lewis and F344 rats. In a second set of experiments an i...